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Arm_group: carboplatin + paclitaxel + fluorouracil + radiation + surgery (Arm Group) [RDF]

Label carboplatin + paclitaxel + fluorouracil + radiation + surgery (Arm Group)
Slug 22afdd3f9f2c4295df88f41947ce0bd6
Arm group label carboplatin + paclitaxel + fluorouracil + radiation + surgery
Description Patients receive carboplatin IV and paclitaxel IV over 3 hours on days 1 and 22 and fluorouracil IV continuously on days 1-42. Beginning on day 1 of chemotherapy, patients undergo radiotherapy to the esophagus 5 days a week for 5 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients with stable or responding disease at 4-8 weeks after completion of radiotherapy undergo esophagectomy and complete dissection of the mediastinal and perigastric lymph nodes. Beginning 8 weeks after surgery, patients who underwent curative resection may receive a maximum of 2 additional courses of paclitaxel and carboplatin in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, before chemotherapy on days 1 and 22, and within 2 weeks before surgery. Patients are followed every 3 months for 4 years.
Arm group type Experimental
Provenances http://clinicaltrials.gov/show/NCT00022139?displayxml=true
Similars None
Interlinks None