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Eligibility: 36397d71d74cffca2f61b9f6c6736b55 [RDF]

Label 36397d71d74cffca2f61b9f6c6736b55
Slug 36397d71d74cffca2f61b9f6c6736b55
Criteria DISEASE CHARACTERISTICS: - Histologically proven metastatic renal cell carcinoma not amenable to complete surgical resection and progressive despite immunotherapy - Bidimensionally evaluable clinically or radiographically - HLA 6/6 or 5/6 matched family donor available - No CNS metastases PATIENT CHARACTERISTICS: Age: - 18 to 80 Performance status: - ECOG 0 or 1 Life expectancy: - At least 3 months Hematopoietic: - Not specified Hepatic: - Bilirubin no greater than 4 mg/dL - Transaminases no greater than 3 times upper limit of normal Renal: - Creatinine no greater than 2.5 mg/dL - No malignancy-associated hypercalcemia (< 2.5 mmol/L) Cardiovascular: - Left ventricular ejection fraction greater than 40% Pulmonary: - DLCO greater than 65% of predicted Other: - Not pregnant - HIV negative - No major organ dysfunction that would preclude transplantation - No other malignancies except basal cell or squamous cell skin cancer - No psychiatric disorder or mental deficiency that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy - See Disease Characteristics Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified Other - At least 1 month since prior treatment for renal cell carcinoma
Maximum age 80 Years
Healthy volunteers No
Study pop
Minimum age 18 Years
Gender All
Sampling method
Similars None
Interlinks None